CRISPR-Cas9 technology has revolutionized the field of genome editing, offering unprecedented precision and efficiency in targeted genetic modifications. One of the critical components of CRISPR-mediated genome editing is the delivery of single guide RNA (sgRNA) to the target cells. Optimizing sgRNA delivery methods is crucial for maximizing the efficiency and specificity of CRISPR editing. In this blog post, we will explore various strategies for enhancing sgRNA delivery, thereby improving CRISPR efficiency.

DNA electrophoresis is a very important and common technique in the field of life sciences, allowing researchers to analyze the size and structure of DNA fragments and uncover the mysteries of the genome. In this field, FLUORESCENT ssDNA LADDER is emerging as a new favorite among researchers.

If you have been working with us for a couple of years, you probably already noticed that our single-molecule FISH Probes changed names and are not called HuluFISH Probes anymore, but NovaFISH Probes. However, not only was it the name that changed, but also did the structure.

Cell transfection techniques are commonly used in research to effectively introduce exogenous DNA, RNA, or proteins into cells for purposes such as gene editing and protein expression. Electroporation and lipofection are two common transfection methods that play important roles in the field of cell transfection. Electroporation utilizes brief high-voltage pulses to increase the permeability of cell membranes, allowing exogenous DNA or RNA to enter the cells, while lipofection involves the formation of complexes between lipids and exogenous DNA or RNA, which then bind to the cell membrane and are engulfed by the cell, facilitating the entry of exogenous molecules into the cytoplasm. This study aims to compare the knockout efficiency of these two transfection methods for Cas9 protein and mRNA in Hek 293T and HeLa cells to reveal the impact of different transfection methods on gene editing efficiency in two cell types.

CATUG Inc. (CATUG) and PixelBiosciences (PixelBio), announced today a long-term strategic partnership towards providing high quality RNA materials, research tools and advanced CRO services in the field of gene editing and cell therapy. Together, CATUG, a distinguished global entity specializing in high quality messenger RNA (mRNA) and lipid nanoparticle (LNP) formulation CRDMO services, and PixelBio, a premier provider of high purity single guide RNA (sgRNA) to empower professionals engaged in gene editing research and RNA-based therapeutics development.

We have today a very short blog for an easy read about one of our products that is least mentioned: the fluorescent ssDNA ladder.